Pharmacodynamic studies of nitrofurantoin against common uropathogens
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چکیده
منابع مشابه
Excretion studies of nitrofurantoin and nitrofurantoin with deglycyrrhizinated liquorice.
Nitrofurantoin and nitrofurantoin with liquorice were given to healthy volunteers and patients suffering from urinary tract infections. The excretion rates of the drug, colony counts and side effects were studied in patients and excretion rates in the volunteers. The excretion rates of the drug were significantly higher in patients receiving the drug with liquorice and also side effects were mi...
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264 The Journal of Clinical Pharmacology T HE effects of dosage form variables on therapeutic efficacy and/or bioavailability of drugs are well documented.m Usually, these effects will be manifest principally in differences in rate of absorption and/or differences in efficiency of absorption. Since a formulation which releases a drug slowly over an extended time could have the same bioavailabil...
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The activity of nitrofurantoin was tested against 300 isolates of Enterococcus faecium, Enterococcus faecalis, and Enterococcus gallinarum. No isolates tested were resistant to nitrofurantoin (MIC, >/=128 microg/ml), including vancomycin-resistant E. faecium isolates with vanA- and vanB-positive genotypes and vancomycin-resistant E. gallinarum isolates. We conclude that nitrofurantoin may provi...
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TO THE EDITOR—Urinary tract infections (UTIs) remain a common indication for antibiotic therapy in children [1]. They are frequently managed in the outpatient setting where availability of susceptibility results may be delayed, making selection of appropriate initial therapy important. We sought to evaluate susceptibility patterns of antibiotic agents used to treat UTIs in children by developin...
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BACKGROUND Newer quinolones are highly active against Legionella pneumophila. Since this pathogen is intracellular, standard in vitro susceptibility tests may not accurately predict clinical efficacy. Few models for studies of intracellular Legionella have been described. In this study, we determined the pharmacodynamic activity of moxifloxacin against intracellular L. pneumophila in comparison...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2014
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dku494